Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29257891 | 0.86 | NR1H2 (0.60) | NR1H2KDM4EPKMGLSMEN1 | |
| SCHEMBL584378 | 0.85 | KDM4E (0.54) | NR1H2KDM4EPKMGLSMAPT | |
| SCHEMBL22181462 | 0.85 | NR1H2 (0.46) | NR1H2KDM4EPKMGLSMEN1 | |
| SCHEMBL22181202 | 0.84 | NR1H2 (0.51) | NR1H2KDM4EPKMMEN1ALDH1A1 | |
| SCHEMBL29257828 | 0.84 | NR1H2 (0.43) | NR1H2KDM4EPKMGLSMEN1 | |
| SCHEMBL28063864 | 0.84 | KDM4E (0.53) | NR1H2KDM4EPKMGLSMAPT | |
| SCHEMBL15777351 | 0.83 | NR1H2 (0.43) | NR1H2KDM4EPKMGLSALDH1A1 | |
| SCHEMBL345307 | 0.82 | KDM4E (0.49) | NR1H2KDM4EPKMGLSMEN1 | |
| SCHEMBL874037 | 0.82 | KDM4E (0.49) | NR1H2KDM4EPKMGLSMEN1 | |
| SCHEMBL345306 | 0.82 | KDM4E (0.49) | NR1H2KDM4EPKMGLSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390785-A | BET family bromodomain inhibitor ring derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2021-02-23 | — | — | CN | disclosed |