Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 19/20 | 0.47 |
| ▸ | STAT5B | P51692 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853902 | 0.89 | STAT3 (0.56) | STAT3STAT5BLTB4R2 | |
| Meglumine SCHEMBL4456782 | 0.87 | STAT3 (0.38) | STAT3STAT5B | |
| SCHEMBL2853550 | 0.81 | STAT3 (0.46) | STAT3STAT5B | |
| SCHEMBL1733819 | 0.80 | STAT3 (0.49) | STAT3STAT5B | |
| SCHEMBL1734773 | 0.79 | STAT3 (0.50) | STAT3STAT5B | |
| SCHEMBL2853623 | 0.79 | STAT3 (0.53) | STAT3STAT5B | |
| SCHEMBL1733846 | 0.77 | PTPN11 (0.51) | STAT3STAT5B | |
| Meglumine SCHEMBL4452475 | 0.76 | STAT3 (0.57) | STAT3 | |
| Meglumine SCHEMBL4461973 | 0.75 | CNR2 (0.45) | STAT3STAT5B | |
| SCHEMBL13711757 | 0.74 | STAT3 (0.48) | STAT3STAT5BLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | disclosed |