Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 11/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meglumine SCHEMBL2853649 | 0.88 | STAT3 (0.45) | STAT3 | |
| SCHEMBL2856083 | 0.88 | STAT3 (0.71) | STAT3PDK1NPC1RAB9APDK2 | |
| Meglumine SCHEMBL4458998 | 0.87 | STAT3 (0.47) | STAT3PDK1PDK2PDK4 | |
| Meglumine SCHEMBL4461973 | 0.83 | CNR2 (0.45) | STAT3 | |
| Meglumine SCHEMBL4454874 | 0.83 | STAT3 (0.46) | STAT3 | |
| SCHEMBL13711702 | 0.81 | STAT3 (0.75) | STAT3PDK1NPC1RAB9APDK2 | |
| Meglumine SCHEMBL2852826 | 0.76 | STAT3 (0.47) | STAT3 | |
| SCHEMBL2853433 | 0.74 | STAT3 (0.75) | STAT3PDK2PDK4 | |
| SCHEMBL2855112 | 0.74 | STAT3 (0.57) | STAT3PDK2PDK4 | |
| SCHEMBL17077004 | 0.73 | STAT3 (1.00) | STAT3PDK1PDK2PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589232-B2 | Alkynyl aryl carboxamides | LABORATORIES SERONO S.A. (CH) | 2009-09-15 | — | — | US | disclosed |
| US-20070105913-A1 | Alkynyl aryl carboxamides | APPLIED RESEARCH SYSTEMS ARS HOLDINGS N.V. (NL) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105913-A1 | Alkynyl aryl carboxamides | ECHS1, IRS1, HCCS | STAT3 2684/4885PDK1 146/4885NPC1 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.