Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28527640 | 0.91 | CSF1R (0.59) | CSF1RKCNH2INSRKITSRC | |
| SCHEMBL28522952 | 0.88 | CSF1R (0.59) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL28526528 | 0.86 | CSF1R (0.69) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL28909928 | 0.84 | CSF1R (0.53) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL28540961 | 0.84 | CSF1R (0.54) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL28528317 | 0.82 | CSF1R (0.54) | CSF1RINSRKITSRCFLT3 | |
| SCHEMBL28908007 | 0.81 | CSF1R (0.59) | CSF1RKCNH2PDE4APDE4BPDE4C | |
| SCHEMBL28538552 | 0.79 | CSF1R (0.52) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL28530555 | 0.79 | CSF1R (0.55) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL28527132 | 0.77 | CSF1R (0.64) | CSF1RKITSRCFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |