Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CCR1 | P32246 | 4/20 | 0.51 |
| ▸ | GPR6 | P46095 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.47 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.47 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15074687 | 0.88 | KDM4E (0.59) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL10366977 | 0.88 | KMT2A (0.60) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL28696410 | 0.87 | ALDH1A1 (0.76) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL10367084 | 0.86 | ALDH1A1 (0.76) | KDM4EALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL10365015 | 0.86 | TRPC3 (0.70) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL10367046 | 0.86 | KDM4E (0.57) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL13513682 | 0.85 | MAPT (0.57) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL10367050 | 0.85 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL2856010 | 0.83 | MAPT (0.58) | KDM4EALDH1A1MAPTTRPC3POLB | |
| SCHEMBL2064195 | 0.83 | MAPT (0.76) | KDM4EALDH1A1MAPTTRPC3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4620865-A | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides | ELI LILLY AND COMPANY (US) | 1986-11-04 | — | — | US | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |
| EP-0151866-B1 | HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
| US-4620865-A | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides | ELI LILLY AND COMPANY (US) | 1986-11-04 | — | — | US | disclosed |