Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.32 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30544155 | 1.00 | POLB (0.38) | POLBMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL28661419 | 0.83 | MAPT (0.42) | POLBMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL29427867 | 0.83 | MAPT (0.42) | POLBMAPTALDH1A1HPGDRAB9A | |
| SCHEMBL29427882 | 0.80 | KRAS (0.33) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL22623071 | 0.80 | KRAS (0.33) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL24069476 | 0.75 | CLCN2 (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2GAA | |
| SCHEMBL30106566 | 0.75 | CLCN2 (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2GAA | |
| SCHEMBL29427879 | 0.75 | CLCN2 (0.51) | CLCN2 | |
| SCHEMBL28783719 | 0.74 | POLB (0.35) | POLBKRAS | |
| SCHEMBL31361068 | 0.74 | ALDH1A1 (0.44) | POLBMAPTALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390818-B | Substituted heteroaromatic dihydro pyrimidinone derivatives, their preparation and pharmaceutical use | 劲方医药科技(上海)有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-112390818-A | Substituted heteroaromatic dihydro pyrimidone derivatives, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2021-02-23 | — | — | CN | disclosed |