Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | F2R | P25116 | 7/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 3/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28539670 | 1.00 | HTR2C (0.42) | HTR2CF2RNOTUMDRD5P2RY14 | |
| SCHEMBL28606430 | 0.88 | HTR2C (0.44) | HTR2CF2RNOTUMDRD5P2RY14 | |
| SCHEMBL23632103 | 0.88 | HTR2C (0.44) | HTR2CF2RNOTUMDRD5P2RY14 | |
| SCHEMBL28535453 | 0.84 | MAPK1 (0.41) | F2RFPR1KDM4EALDH1A1POLB | |
| SCHEMBL28546435 | 0.84 | MAPK1 (0.41) | F2RFPR1KDM4EALDH1A1POLB | |
| SCHEMBL25364244 | 0.84 | RAB9A (0.40) | HTR2CHTR1ASIGMAR1PAX8ALDH1A1 | |
| SCHEMBL25364150 | 0.84 | RAB9A (0.40) | HTR2CHTR1ASIGMAR1PAX8ALDH1A1 | |
| SCHEMBL21619693 | 0.82 | TACR1 (0.48) | P2RY14 | |
| SCHEMBL29200058 | 0.82 | TACR1 (0.48) | P2RY14 | |
| SCHEMBL28534495 | 0.82 | TACR1 (0.48) | P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072542-B | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-112513021-B | ROR gamma antagonist and application thereof in medicines | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-113072542-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | disclosed |