Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379741 | 1.00 | JAK2 (0.44) | JAK2JAK3JAK1MAPK10PRKCQ | |
| SCHEMBL30379338 | 0.92 | SLC2A1 (0.46) | JAK2JAK3JAK1MAPK10PRKCQ | |
| SCHEMBL28909341 | 0.92 | SLC2A1 (0.46) | JAK2JAK3JAK1MAPK10PRKCQ | |
| SCHEMBL28533099 | 0.91 | MAPK10 (0.45) | JAK2JAK3JAK1MAPK10PRKCQ | |
| SCHEMBL21599131 | 0.87 | MAPK10 (0.44) | JAK2JAK3JAK1MAPK10PRKCQ | |
| SCHEMBL30379621 | 0.87 | MAPK10 (0.44) | JAK2JAK3JAK1MAPK10PRKCQ | |
| SCHEMBL30379371 | 0.84 | FGFR4 (0.51) | JAK3FGFR1 | |
| SCHEMBL21596399 | 0.84 | FGFR4 (0.51) | JAK3FGFR1 | |
| SCHEMBL28534420 | 0.84 | MAPK10 (0.42) | JAK2JAK3JAK1MAPK10CDK4 | |
| SCHEMBL28909404 | 0.84 | MAPK10 (0.50) | JAK2JAK3JAK1MAPK10CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |