Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.30 |
| ▸ | PARP1 | P09874 | 4/20 | 0.30 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.30 |
| ▸ | F7 | P08709 | 1/20 | 0.30 |
| ▸ | F3 | P13726 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28539135 | 0.83 | MAP3K5 (0.38) | MAP3K5GSK3BGRM5GRM1PARP10 | |
| SCHEMBL28541383 | 0.81 | MAP3K5 (0.35) | MAP3K5GSK3BGRM5GRM1 | |
| SCHEMBL28607413 | 0.81 | MAP3K5 (0.38) | MAP3K5KDM4EGSK3BGRM5GRM1 | |
| SCHEMBL22473965 | 0.81 | PARP10 (0.41) | MAP3K5KDM4EGSK3BGRM5GRM1 | |
| SCHEMBL28941273 | 0.80 | PARP10 (0.40) | MAP3K5KDM4EGRM5GRM1PARP10 | |
| SCHEMBL28887761 | 0.80 | PARP10 (0.40) | MAP3K5KDM4EGSK3BGRM5GRM1 | |
| SCHEMBL20489212 | 0.80 | MAP3K5 (0.49) | MAP3K5KDM4EPARP10PARP1PARP11 | |
| SCHEMBL29978642 | 0.80 | MAP3K5 (0.49) | MAP3K5KDM4EPARP10PARP1PARP11 | |
| SCHEMBL30362996 | 0.80 | PARP10 (0.40) | MAP3K5KDM4EGRM5GRM1PARP10 | |
| SCHEMBL28910942 | 0.76 | MAP3K5 (0.39) | MAP3K5KDM4EGSK3BGRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071498-B | Kinase inhibitor and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2021-03-30 | — | — | CN | disclosed |