Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F known ✓ | O60840 | 1/20 | 0.48 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.48 |
| ▸ | CACNA1D known ✓ | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S known ✓ | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 14/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.61 |
| ▸ | CSF1R | P07333 | 3/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.61 |
| ▸ | KIT | P10721 | 7/20 | 0.49 |
| ▸ | FLT3 | P36888 | 6/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL28533606 | 1.00 | KDR (0.61) | KDRPDGFRBCSF1RABCB11KIT | |
| Malic Acid SCHEMBL29904180 | 1.00 | KDR (0.61) | KDRPDGFRBCSF1RABCB11KIT | |
| SCHEMBL4566613 | 0.91 | KDR (0.55) | KDRPDGFRBCSF1RABCB11KIT | |
| SCHEMBL28641704 | 0.91 | KDR (0.55) | KDRPDGFRBCSF1RABCB11KIT | |
| SCHEMBL28900853 | 0.86 | KDR (0.56) | KDRPDGFRBCSF1RABCB11KIT | |
| SCHEMBL16569734 | 0.78 | FLT3 (0.52) | KDRPDGFRBCSF1RABCB11KIT | |
| Famitinib SCHEMBL154539 | 0.77 | KDR (0.84) | KDRPDGFRBCSF1RABCB11KIT | |
| Famitinib SCHEMBL29361661 | 0.77 | KDR (0.84) | KDRPDGFRBCSF1RABCB11KIT | |
| Famitinib SCHEMBL29361816 | 0.77 | KDR (0.84) | KDRPDGFRBCSF1RABCB11KIT | |
| Famitinib SCHEMBL154540 | 0.77 | KDR (0.84) | KDRPDGFRBCSF1RABCB11KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117723665-A | Detection method for sunitinib malate capsule related substances | 山东百诺医药股份有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-112451499-B | Sunitinib malate preparation and preparation method thereof | 江苏豪森药业集团有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-112451499-A | Sunitinib malate preparation and preparation method thereof | 江苏豪森药业集团有限公司 | 2021-03-09 | — | — | CN | disclosed |