Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.55 |
| ▸ | FLT3 | P36888 | 6/20 | 0.55 |
| ▸ | KIT | P10721 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28641704 | 1.00 | KDR (0.55) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| SCHEMBL28900853 | 0.92 | KDR (0.56) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| Malic Acid SCHEMBL29904180 | 0.91 | KDR (0.61) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| Malic Acid SCHEMBL28533602 | 0.91 | KDR (0.61) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| Malic Acid SCHEMBL28533606 | 0.91 | KDR (0.61) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| SCHEMBL16569734 | 0.84 | FLT3 (0.52) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| SCHEMBL19862519 | 0.82 | KDR (0.67) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| SCHEMBL19645259 | 0.82 | KDR (0.71) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| SCHEMBL28673602 | 0.82 | ALK (0.45) | KDRPDGFRBPRKAA1PRKAA2FLT3 | |
| SCHEMBL28666353 | 0.82 | ALK (0.45) | KDRPDGFRBPRKAA1PRKAA2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168218-B1 | A CRYSTAL COMPRISING AN L-MALIC ACID SALT OF N-[2-(DIETHYLAMINO)ETHYL]-5-[(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE FOR USE AS A MEDICAMENT | PHARMACIA & UPJOHN CO LLC (US) | 2018-11-14 | — | — | EP | claimed |
| CN-110016052-B | Phosphoramide derivative of N-deethylsunitinib and preparation method thereof | 四川海思科制药有限公司 | 2021-09-28 | — | — | CN | disclosed |
| CN-101495513-A | Angiopoietin-2 specific binding agents | AMGEN INC (US) | 2009-07-29 | — | — | CN | disclosed |
| WO-2009021150-A2 | PLATELET DERIVED GROWTH FACTOR RECEPTOR SUPPORTS CYTOMEGALOVIRUS INFECTIVITY | CALIFORNIA PACIFIC MEDICAL CENTER (US) | 2009-02-12 | — | — | WO | disclosed |