Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15510719 | 0.95 | — | — | |
| SCHEMBL113503 | 0.95 | — | — | |
| Ethylene Glycol SCHEMBL27835504 | 0.93 | TSHR (0.46) | TSHRUSP2ALDH1A1CNR1CNR2 | |
| SCHEMBL8506709 | 0.92 | — | — | |
| Isopropyl Alcohol SCHEMBL1641692 | 0.92 | TSHR (0.39) | TSHRUSP2ALDH1A1CNR1CNR2 | |
| Water SCHEMBL9170507 | 0.92 | — | — | |
| Methyl Alcohol SCHEMBL14895379 | 0.92 | TSHR (0.39) | TSHRUSP2ALDH1A1CNR1CNR2 | |
| Butyl Alcohol SCHEMBL27802091 | 0.91 | ALDH1A1 (0.50) | TSHRUSP2ALDH1A1CNR1CNR2 | |
| Isopropyl Alcohol SCHEMBL27549168 | 0.91 | TSHR (0.44) | TSHRUSP2ALDH1A1CNR1CNR2 | |
| Ethylene SCHEMBL4948081 | 0.90 | TSHR (0.37) | TSHRUSP2ALDH1A1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1188578-B1 | Method of lithographic printing with a reusable substrate | AGFA GEVAERT (BE) | 2004-03-31 | — | — | EP | claimed |
| CN-111885994-B | PVD aluminum pigment dispersions and cosmetic formulations | 埃卡特有限公司 | 2024-01-30 | — | — | CN | disclosed |
| US-9555166-B2 | Medical device with coating that promotes endothelial cell adherence | ORBUSNEICH MEDICAL INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150352263-A1 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE | ORBUSNEICH MEDICAL PTE. LTD. (SG) | 2015-12-10 | — | — | US | disclosed |
| US-20150352261-A1 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE | ORBUSNEICH MEDICAL PTE. LTD. (SG) | 2015-12-10 | — | — | US | disclosed |
| US-9072723-B2 | Medical device with coating that promotes endothelial cell adherence | ORBUS MEDICAL TECHNOLOGY INC (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130035755-A1 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE | ORBUSNEICH MEDICAL, INC. (US) | 2013-02-07 | — | — | US | disclosed |
| US-7803183-B2 | Medical device with coating that promotes endothelial cell adherence | ORBUSNEICH MEDICAL, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20070156232-A1 | Medical Device with Coating that Promotes Endothelial Cell Adherence | ORBUSNEICH MEDICAL, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| EP-1263484-B1 | COATING WHICH PROMOTES ENDOTHELIAL CELL ADHERENCE | ORBUSNEICH MEDICAL INC (US) | 2007-05-16 | — | — | EP | disclosed |
| US-7037332-B2 | A coating rendering the stent or synthetic graft compatible for in vivo attachment and proliferation of cells on the surface, containing a therapeutical antibody which reacts with an endothelial cell surface antigen | ORBUS MEDICAL TECHNOLOGIES, INC. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20050043787-A1 | Medical device with coating that promotes endothelial cell adherence | ORBUS MEDICAL TECHNOLOGIES INC. | 2005-02-24 | — | — | US | disclosed |
| EP-1263484-A1 | COATING WHICH PROMOTES ENDOTHELIAL CELL ADHERENCE | Orbus Medical Technologies, Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020049495-A1 | Medical device with coating that promotes endothelial cell adherence | ORBUSNEICH MEDICAL PTE. LTD. (SG) | 2002-04-25 | — | — | US | disclosed |
| WO-2001068158-A1 | COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE | ORBUS MEDICAL TECHNOLOGIES INC. (US) | 2001-09-20 | — | — | WO | disclosed |