Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348200 | 0.87 | KDM4E (0.50) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL1347932 | 0.86 | HPGD (0.54) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL14827417 | 0.86 | KDM4E (0.64) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL1348484 | 0.84 | TTR (0.48) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL1348320 | 0.80 | GSK3B (0.47) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL1348330 | 0.80 | HSD17B10 (0.48) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL312553 | 0.79 | KDM4E (0.75) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL1347467 | 0.79 | KDM4E (0.47) | KDM4EMAPTHPGDALDH1A1HSD17B10 | |
| SCHEMBL1348338 | 0.75 | LMNA (0.45) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL313181 | 0.75 | CSNK2A1 (0.56) | KDM4EMAPTHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863818-B1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-03-10 | — | — | EP | disclosed |