Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.64 |
| ▸ | CASR | P41180 | 6/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.48 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30596350 | 1.00 | NOTUM (0.64) | NOTUMCASRCHRM4ACACBDHFR | |
| SCHEMBL2854873 | 0.84 | CASR (0.46) | NOTUMCASRCHRM4CHRM2CHRM1 | |
| SCHEMBL8038976 | 0.81 | DPP4 (0.55) | DHFRFFAR4 | |
| SCHEMBL21624885 | 0.79 | NOTUM (0.63) | NOTUMCASR | |
| SCHEMBL2854862 | 0.79 | NOTUM (0.63) | NOTUMCASR | |
| SCHEMBL3060159 | 0.79 | NOTUM (0.59) | NOTUMCASRCHRM4ACACBDHFR | |
| Hydrochloric Acid SCHEMBL9312337 | 0.78 | NOTUM (0.61) | NOTUMCASR | |
| SCHEMBL32665255 | 0.78 | NOTUM (0.43) | NOTUM | |
| SCHEMBL32665250 | 0.78 | NOTUM (0.43) | NOTUM | |
| SCHEMBL2444666 | 0.78 | NOTUM (0.62) | NOTUMCASRCHRM4ACACBDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| CN-116806217-A | Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof | 拉帕塔疗法公司 | 2023-09-26 | — | — | CN | disclosed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |