Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 8/20 | 0.42 |
| ▸ | HTR2B | P41595 | 6/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32665250 | 1.00 | NOTUM (0.43) | NOTUMHTR6HTR2BHTR1ADRD2 | |
| SCHEMBL32665624 | 0.92 | VCP (0.42) | NOTUMHTR6HTR2BBPTFALDH1A1 | |
| SCHEMBL32665273 | 0.81 | NOTUM (0.38) | NOTUMBPTFALDH1A1SMN1; SMN2 | |
| SCHEMBL32665449 | 0.80 | BPTF (0.51) | NOTUMHTR6HTR1ABPTFALDH1A1 | |
| SCHEMBL32665174 | 0.79 | NOTUM (0.40) | NOTUMBPTFALDH1A1MTNR1AMTNR1B | |
| SCHEMBL32665450 | 0.79 | NOTUM (0.40) | NOTUMBPTFALDH1A1MTNR1AMTNR1B | |
| SCHEMBL8038976 | 0.79 | DPP4 (0.55) | DRD2KHKALDH1A1DPP4MTNR1A | |
| SCHEMBL30596350 | 0.78 | NOTUM (0.64) | NOTUM | |
| SCHEMBL2853626 | 0.78 | NOTUM (0.64) | NOTUM | |
| SCHEMBL32665285 | 0.75 | ALDH1A1 (0.36) | NOTUMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260021192-A1 | PROTEINS HAVING A COVALENT WARHEAD | TOPAZ THERAPEUTICS INC (US) | 2026-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260021192-A1 | PROTEINS HAVING A COVALENT WARHEAD | RIOX2, ORC3, DCLRE1A | NOTUM 4135/4885HTR6 4206/4885HTR2B 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.