Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 13/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meglumine SCHEMBL4461973 | 0.89 | CNR2 (0.45) | STAT3PTPN11PTPRO | |
| Meglumine SCHEMBL4454874 | 0.89 | STAT3 (0.46) | STAT3PTPN11PTPROPTGESLTB4R2 | |
| Meglumine SCHEMBL4452475 | 0.88 | STAT3 (0.57) | STAT3 | |
| Meglumine SCHEMBL4458998 | 0.87 | STAT3 (0.47) | STAT3PTPN11PTPROPTGESLTB4R2 | |
| SCHEMBL2855112 | 0.85 | STAT3 (0.57) | STAT3PTPN11PTPROHNF4ALTB4R2 | |
| Meglumine SCHEMBL1813196 | 0.78 | PTPN11 (0.75) | STAT3PTPN11PTPROLTB4R2 | |
| SCHEMBL13711792 | 0.76 | STAT3 (0.67) | STAT3LTB4R2 | |
| Meglumine SCHEMBL1814503 | 0.76 | PTPN11 (0.62) | STAT3PTPN11PTPROPTGES | |
| Meglumine SCHEMBL4456885 | 0.74 | PTPN11 (0.44) | STAT3PTPN11PTPROLTB4R2 | |
| SCHEMBL2856083 | 0.73 | STAT3 (0.71) | STAT3PTPN11PTPRO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | disclosed |