Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 4/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853223 | 0.88 | LTB4R2 (0.45) | FFAR1ACACB | |
| SCHEMBL13708347 | 0.87 | ACACB (0.42) | ALDH1A1ACACB | |
| SCHEMBL2858113 | 0.83 | PTPN11 (0.47) | PTPN11PTPROALDH1A1HPGDFFAR1 | |
| SCHEMBL13711647 | 0.79 | LTB4R2 (0.53) | NPC1 | |
| SCHEMBL2855523 | 0.78 | PTPN11 (0.43) | PTPN11PTPROALDH1A1HPGDFFAR1 | |
| SCHEMBL13711665 | 0.78 | LTB4R2 (0.43) | ALDH1A1NPC1 | |
| SCHEMBL2861907 | 0.73 | PDE6D (0.48) | PTPN11PTPROFFAR1FFAR4PLK1 | |
| SCHEMBL1734728 | 0.72 | LTB4R2 (0.53) | PTPN11PTPROFFAR1FFAR4NPC1 | |
| SCHEMBL2854924 | 0.71 | RARB (0.55) | PTPN11PTPROALDH1A1FFAR1FFAR4 | |
| SCHEMBL2859208 | 0.71 | ACACB (0.43) | PTPN11PTPROACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654247-B1 | ALKYNYL ARYL CARBOXAMIDES | MERCK SERONO SA (CH) | 2010-01-20 | — | — | EP | claimed |