SCHEMBL28536985

SCHEMBL28536985

CC(=O)Cc1ccc([N+](=O)[O-])c(Cl)c1[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.43
PDK1 Q15118 1/20 0.41
CYP1A2 P05177 2/20 0.39
KMT2A Q03164 2/20 0.39
ATM Q13315 1/20 0.39
OPRK1 P41145 1/20 0.37
NPC1 O15118 3/20 0.37
RAB9A P51151 3/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
LMNA P02545 2/20 0.35
MAPT P10636 2/20 0.35
CYP2C9 P11712 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28337354 0.81 CYP1A2 (0.39) TDP1PDK1CYP1A2KMT2AATM
SCHEMBL28240034 0.80 TDP1 (0.48) TDP1PDK1CYP1A2NPC1RAB9A
SCHEMBL2803959 0.78 CYP1A2 (0.39) TDP1PDK1CYP1A2KMT2AATM
SCHEMBL3006053 0.76 TSHR (0.51) PDK1CYP1A2KMT2AATMNPC1
SCHEMBL3014357 0.76 NPC1 (0.51) TDP1PDK1CYP1A2KMT2AATM
SCHEMBL28256134 0.73 TDP1 (0.61) TDP1CYP1A2ATMCYP3A4CYP2C19
SCHEMBL28964217 0.73 CYP1A2 (0.54) TDP1PDK1CYP1A2NPC1RAB9A
SCHEMBL19182459 0.72 CYP1A2 (0.53) TDP1PDK1CYP1A2MAPTHTT
SCHEMBL28343885 0.72 TDP1 (0.43) TDP1PDK1CYP1A2KMT2ANPC1
SCHEMBL31046181 0.71 KMT2A (0.59) KMT2ANPC1RAB9ACYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118161560-A External powder for treating acute eczema and preparation method thereof 湖北中医药大学 2024-06-11 CN disclosed
CN-116077381-A Skin care composition, tissue and preparation method thereof 蒋世东 2023-05-09 CN disclosed
CN-114480208-A Direct-vat probiotic starter for relieving immune diseases and application thereof 微康益生菌(苏州)股份有限公司 2022-05-13 CN disclosed
CN-113893212-A Traditional Chinese medicine mask for resisting inflammation and relieving itching and preparation method thereof 合江妙灵中药材开发有限公司 2022-01-07 CN disclosed
CN-112494374-A Hair loss prevention shampoo and preparation method and application method thereof 上海章华保健化妆品有限公司 2021-03-16 CN disclosed