Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28337354 | 0.88 | CYP1A2 (0.39) | CYP1A2PDK1TSHRGPR35TXNRD1 | |
| SCHEMBL6836629 | 0.86 | L3MBTL1 (0.34) | CYP1A2PDK1ATMTDP1KMT2A | |
| SCHEMBL28536985 | 0.78 | TDP1 (0.43) | CYP1A2PDK1TSHRATMTDP1 | |
| SCHEMBL30410464 | 0.76 | CYP1A2 (0.50) | CYP1A2PDK1ATMTDP1KMT2A | |
| SCHEMBL3010413 | 0.76 | ATM (0.51) | CYP1A2PDK1ATMTDP1KMT2A | |
| SCHEMBL2994232 | 0.76 | CYP1A2 (0.50) | CYP1A2PDK1ATMTDP1KMT2A | |
| SCHEMBL3515877 | 0.75 | LMNA (0.41) | CYP1A2TSHRGPR35ATMTDP1 | |
| SCHEMBL297761 | 0.73 | ATM (0.40) | TSHRATMTDP1KMT2AMEN1 | |
| SCHEMBL22284116 | 0.73 | GAA (0.40) | CYP1A2TSHRGPR35TDP1KMT2A | |
| SCHEMBL3390082 | 0.72 | CYP1A2 (0.57) | CYP1A2PDK1TSHRATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107213250-B | Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof | 辽宁中医药大学 | 2020-11-24 | — | — | CN | disclosed |
| EP-2930170-B1 | PYRIDONE COMPOUND FOR USE IN THE TREATMENT OF DERMATOLOGICAL DISORDERS | KYOWA KIRIN CO LTD (JP) | 2020-02-05 | — | — | EP | disclosed |
| EP-2927214-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-03-21 | — | — | EP | disclosed |
| US-9701689-B2 | Substituted pyridines and pyridazines as CCR10 receptor inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-07-11 | — | — | US | disclosed |
| US-9643952-B2 | Pyridone compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-05-09 | — | — | US | disclosed |
| EP-2543670-B1 | PYRAZOLOPYRIMIDIN-DERIVATIVE FÜR DIE BEHANDLUNG VON HAUTKRANKHEITEN | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-05-04 | — | — | EP | disclosed |
| US-20150315172-A1 | PYRIDONE COMPOUND | KYOWA KIRIN CO., LTD. (JP) | 2015-11-05 | — | — | US | disclosed |
| US-20150299214-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-10-22 | — | — | US | disclosed |
| EP-2930170-A1 | PYRIDONE COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2015-10-14 | — | — | EP | disclosed |
| EP-2927214-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2015-10-07 | — | — | EP | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| CN-101878217-B | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO LTD | 2014-01-15 | — | — | CN | disclosed |
| US-20130102620-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2013-04-25 | — | — | US | disclosed |
| EP-2543670-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| CN-102791712-A | Pyrazolopyrimidine Derivatives | KYOWA HAKKO KIRIN CO LTD | 2012-11-21 | — | — | CN | disclosed |
| CN-102776129-A | Isaria cretacea and application thereof | CHUN CAI | 2012-11-14 | — | — | CN | disclosed |
| CN-202408863-U | Device for skin patch test | YICHANG WUJIAGANG DISTR YIKANG DERMATOLOGY RES INST | 2012-09-05 | — | — | CN | disclosed |
| CN-101878217-A | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO LTD | 2010-11-03 | — | — | CN | disclosed |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2206714-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299214-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | ARG1, H1-0, TYR | CYP1A2 908/4885PDK1 3036/4885TSHR 1345/4885 |
| US-20150315172-A1 | PYRIDONE COMPOUND | HRH4, HRH3, HRH1 | CYP1A2 265/4885PDK1 822/4885TSHR 1516/4885 |
| US-20130102620-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | GRK3, NR3C2, NR1I3 | CYP1A2 249/4885PDK1 742/4885TSHR 247/4885 |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | TYR, CUTA, SERPINB1 | CYP1A2 1664/4885PDK1 3146/4885TSHR 4698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.