Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22321541 | 0.92 | MAPT (0.47) | MAPTSIRT6ALDH1A1LMNAOPRM1 | |
| SCHEMBL28751714 | 0.87 | SIRT6 (0.70) | MAPTSIRT6ALDH1A1LMNAHTR6 | |
| Ammonia Solution, Strong SCHEMBL28953580 | 0.85 | MAPT (0.52) | MAPTSIRT6ALDH1A1LMNAHTR6 | |
| SCHEMBL23581157 | 0.84 | MAPT (0.51) | MAPTSIRT6ALDH1A1LMNAHTR6 | |
| SCHEMBL2226779 | 0.84 | SIRT6 (0.74) | MAPTSIRT6ALDH1A1LMNAHTR6 | |
| SCHEMBL30679040 | 0.84 | SIRT6 (0.74) | MAPTSIRT6ALDH1A1LMNAHTR6 | |
| SCHEMBL28543908 | 0.82 | MAPT (0.62) | MAPTSIRT6ALDH1A1LMNAMAPK1 | |
| SCHEMBL21596314 | 0.82 | GAA (0.58) | MAPTLMNAGAARAD52 | |
| SCHEMBL30679050 | 0.80 | MAPT (0.56) | MAPTSIRT6ALDH1A1LMNAHTR6 | |
| SCHEMBL28778503 | 0.79 | GAA (0.58) | MAPTALDH1A1LMNAMAPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |