Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522714 | 0.80 | ESR1 (0.33) | ACHECA12CA1CA2CA9 | |
| SCHEMBL10655346 | 0.74 | ELANE (0.38) | ESR1SMN1; SMN2LMNAL3MBTL1ELANE | |
| SCHEMBL28527246 | 0.73 | THRB (0.37) | HIF1A | |
| SCHEMBL27351614 | 0.69 | KDM4E (0.38) | ACHEESR1HIF1ASMN1; SMN2RECQL | |
| SCHEMBL28855448 | 0.68 | KMT2A (0.41) | ACHEESR1HIF1ASMN1; SMN2RECQL | |
| SCHEMBL30159199 | 0.68 | KMT2A (0.41) | ACHEESR1HIF1ASMN1; SMN2RECQL | |
| SCHEMBL27567008 | 0.67 | MAPT (0.37) | ACHESMN1; SMN2PDE4DRECQLKMT2A | |
| SCHEMBL8439406 | 0.67 | KDM4C (0.38) | ACHEESR1HIF1ASMN1; SMN2RECQL | |
| SCHEMBL27935866 | 0.66 | KMT2A (0.36) | ACHEESR1HIF1ASMN1; SMN2RECQL | |
| SCHEMBL1243155 | 0.64 | HIF1A (0.38) | ACHECA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137557-B | Nrf2 modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-112930347-A | Inhibitors of KEAP1-Nrf2 protein-protein interactions | 詹森药业有限公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-108112251-B | NRF2 modulators | 葛兰素史克知识产权发展有限公司 | 2021-03-05 | — | — | CN | disclosed |