Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18074243 | 0.81 | POLB (0.42) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL18974996 | 0.80 | KDM4E (0.44) | MEN1KMT2ALMNAGAASMN1; SMN2 | |
| SCHEMBL30067738 | 0.80 | KDM4E (0.44) | MEN1KMT2ALMNAGAASMN1; SMN2 | |
| SCHEMBL10743139 | 0.79 | MEN1 (0.40) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL17974970 | 0.73 | MEN1 (0.49) | MEN1KMT2ALMNAGAASMN1; SMN2 | |
| SCHEMBL4402923 | 0.70 | POLB (0.71) | MEN1KMT2APOLBLMNAGAA | |
| SCHEMBL30341829 | 0.70 | POLB (0.71) | MEN1KMT2APOLBLMNAGAA | |
| SCHEMBL29557464 | 0.70 | BRD4 (0.49) | MEN1KMT2ALMNAGAASMN1; SMN2 | |
| SCHEMBL769455 | 0.70 | BRD4 (0.49) | MEN1KMT2ALMNAGAASMN1; SMN2 | |
| SCHEMBL26017423 | 0.70 | BRD4 (0.49) | MEN1KMT2ALMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538071-A | Compounds useful as RAF-1 inhibitors, methods of preparation and uses | 新乡医学院第一附属医院 | 2021-03-23 | — | — | CN | disclosed |