SCHEMBL28539263

SCHEMBL28539263

COCCn1c(=O)n(-c2nnc(C(F)F)s2)c2c(C3(C#N)CC3)c(S(N)(=O)=O)ccc21

nearest known ligand 0.59

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PARG Q86W56 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28910443 0.89 PARG (0.57) PARG
SCHEMBL28533981 0.84 PARG (0.64) PARG
SCHEMBL28536670 0.78 PARG (0.54) PARG
SCHEMBL23282577 0.78 PARG (0.56) PARG
SCHEMBL17845552 0.74 PARG (1.00) PARG
SCHEMBL28531567 0.73 PARG (0.57) PARG
SCHEMBL17845475 0.72 PARG (0.61) PARG
SCHEMBL28542247 0.71 PARG (0.56) PARG
SCHEMBL17845227 0.70 PARG (1.00) PARG
SCHEMBL28909111 0.70 PARG (0.56) PARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112979631-B PARG inhibiting compounds 癌症研究科技有限公司 2024-09-20 CN disclosed
CN-112979631-A PARG inhibiting compounds 癌症研究科技有限公司 2021-06-18 CN disclosed
CN-107295799-B PARG inhibiting compounds 癌症研究科技有限公司 2021-03-16 CN disclosed