SCHEMBL28536670

SCHEMBL28536670

CCn1c(=O)n(-c2nnc(C)s2)c2c(C3(C#N)CC3)c(S(N)(=O)=O)ccc21

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PARG Q86W56 20/20 0.54
ADPRS Q9NX46 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28910443 0.89 PARG (0.57) PARG
SCHEMBL28539263 0.78 PARG (0.59) PARG
SCHEMBL28533981 0.76 PARG (0.64) PARG
SCHEMBL28533960 0.74 PARG (0.51) PARG
SCHEMBL28531567 0.74 PARG (0.57) PARG
SCHEMBL17845293 0.70 PARG (1.00) PARGADPRS
SCHEMBL28524828 0.68 PARG (0.57) PARGADPRS
SCHEMBL30485705 0.66 PARG (0.40) PARG
SCHEMBL20365040 0.65 PARG (0.80) PARGADPRS
SCHEMBL17845654 0.65 PARG (0.45) PARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112979631-B PARG inhibiting compounds 癌症研究科技有限公司 2024-09-20 CN disclosed
CN-112979631-A PARG inhibiting compounds 癌症研究科技有限公司 2021-06-18 CN disclosed
CN-107295799-B PARG inhibiting compounds 癌症研究科技有限公司 2021-03-16 CN disclosed