Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Calcipotriene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 13/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.67 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | GC | P02774 | 1/20 | 0.64 |
| ▸ | RXRA | P19793 | 1/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Calcipotriene SCHEMBL3278756 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL12311926 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL21849105 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL13044528 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL24066882 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL2455296 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL23339038 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL22364326 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL22364325 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR | |
| Calcipotriene SCHEMBL22364327 | 1.00 | VDR (1.00) | VDRADORA3SLC6A2NR1I2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8209 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636262-B2 | Process for the preparation of topical formulation | Neuheit Pharma Technologies Pvt. Ltd. (IN) | 2026-05-26 | — | — | US | claimed |
| US-12616749-B2 | Methods for treatment of psoriasis with an anti-oxLDL antibody | ABCENTRA, LLC (US) | 2026-05-05 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| WO-2026042066-A1 | COMPOUNDS, COMPOSITIONS, AND USE THEREOF FOR TREATING INFLAMMATORY AND/OR AUTOIMMUNE DISEASES | I DERM PHARMA LTD. (IL) | 2026-02-26 | — | — | WO | claimed |
| US-20260035373-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS | ACLARIS THERAPEUTICS INC (US) | 2026-02-05 | — | — | US | claimed |
| EP-4647069-A1 | DRUGS AND COMPOSITIONS FOR USE IN THE TREATMENT OF RETT SYNDROME | UNIVERSITA' DEGLI STUDI DI TRIESTE (IT) | 2025-11-12 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250221982-A1 | COMPOSITIONS AND METHODS FOR LOCAL DELIVERY OF PHARMACEUTICAL AGENTS TO TREAT CANCER | THE GENERAL HOSPITAL CORPORATION | 2025-07-10 | — | — | US | claimed |
| WO-2025137247-A1 | TOPICAL COMPOSITIONS OF GLP-1 AGONISTS AND USE OF GLP-1 AGONISTS AND COMPOSITIONS THEREOF IN TREATING VITILIGO | MILGRAUM SANDY S (US) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129271-A1 | LIPID DELIVERY VEHICLE | THE UNIVERSITY OF QUEENSLAND (AU) | 2025-06-26 | — | — | WO | claimed |
| EP-1067897-A1 | AN ACIDIFIED COMPOSITION FOR TOPICAL TREATMENT OF NAIL AND SKIN CONDITIONS | Johnson & Johnson Consumer Companies, Inc. (US) | 2001-01-17 | — | — | EP | claimed |
| WO-2001001932-A2 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | YU RUEY J (US) | 2001-01-11 | — | — | WO | claimed |
| WO-2000070949-A1 | METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES | HENG MADALENE C Y (US) | 2000-11-30 | — | — | WO | claimed |
| WO-2000057845-A1 | METHOD FOR REMOVAL OF HUMAN HORNY TISSUES | JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) | 2000-10-05 | — | — | WO | claimed |
| US-6087385-A | AN ANTIPROLIFERATIVE, ANTIINFLAMMATORY AND ANTIINFECTIVE AGENTS FOR THE TREATMENT OF CERTAIN ENDOCRINE DISEASES LIKE DIABETES, PROSTATE CANCER, BREAST CANCER, PSORIASIS, ACNE, CERTAIN CARDIOVASCULAR DISORDERS INCLUDING HYPERTENSION | UNIVERSITY OF MISSISSIPPI (US) | 2000-07-11 | — | — | US | claimed |
| US-6028088-A | USEFUL AS ANTIPROLIFERATIVE, ANTIINFLAMMATORY AND ANTIINFECTIVE AGENTS; FOR TREATMENT OF CERTAIN ENDOCRINE DISEASES INCLUDING DIABETES, CERTAIN MALIGNANT AND NON-MALIGNANT PROLIFERATIVE DISEASES INCLUDING PROSTATE CANCER | THE UNIVERSITY OF MISSISSIPPI (US) | 2000-02-22 | — | — | US | claimed |
| WO-1999049835-A1 | AN ACIDIFIED COMPOSITION FOR TOPICAL TREATMENT OF NAIL AND SKIN CONDITIONS | JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) | 1999-10-07 | — | — | WO | claimed |
| US-5824313-A | ADMINISTERING SPECIFIC ANTIGEN AND LYMPHOID ORGAN MODIFYING AGENT SELECTED FROM CALCIPOTRIENE AND 1,25-DIHYDROXY-16-ENE VITAMIN D3; IMMUNE RESONSE AGAINST HEPATITIS, FLU, DIPHTHERIA, TETANUS, PERTUSSIS, MEASLES, MUMPS, RUBELLA, POLIO, PNEUMONIA, | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 1998-10-20 | — | — | US | claimed |
| WO-1998020866-A2 | METHOD OF TREATING KAPOSI'S SARCOMA BY VITAMIN-D3 RECEPTOR AGONISTS | GILL PARKASH S (US) | 1998-05-22 | — | — | WO | claimed |
| WO-1996014048-A1 | TREATMENT OF KERATINIC AND PSORIATIC DISORDERS WITH A NAIL LACQUER CONTAINING A VITAMIN D METABOLITE OR DERIVATIVE AND/OR A VITAMIN A DERIVATIVE | SEIDENSCHNUR EDEL K (DK) | 1996-05-17 | — | — | WO | claimed |