Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 17/20 | 0.85 |
| ▸ | KDR | P35968 | 5/20 | 0.68 |
| ▸ | CSF1R | P07333 | 3/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.68 |
| ▸ | FLT1 | P17948 | 2/20 | 0.68 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28523144 | 0.92 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL28535279 | 0.91 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL28527661 | 0.85 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL28523147 | 0.85 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL30522734 | 0.85 | FLT3 (0.75) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL30237472 | 0.84 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL28907830 | 0.84 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL30522741 | 0.84 | FLT3 (0.74) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL14854691 | 0.84 | KDR (0.68) | FLT3KDRCSF1RPDGFRBPDGFRA | |
| SCHEMBL28524712 | 0.82 | FLT3 (1.00) | FLT3KDRCSF1RPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321568-A | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2021-02-05 | — | — | CN | claimed |
| CN-112321568-B | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2023-02-17 | — | — | CN | disclosed |
| CN-112321568-A | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2021-02-05 | — | — | CN | disclosed |