Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 15/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.71 |
| ▸ | KDR | P35968 | 2/20 | 0.71 |
| ▸ | CSF1R | P07333 | 1/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.71 |
| ▸ | FLT1 | P17948 | 1/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30237472 | 1.00 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28523147 | 0.94 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28524804 | 0.88 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28523144 | 0.87 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28527661 | 0.86 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28529100 | 0.85 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28540205 | 0.84 | FLT3 (0.85) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL28535279 | 0.84 | FLT3 (1.00) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| SCHEMBL30522734 | 0.83 | FLT3 (0.75) | FLT3PDGFRBKDRCSF1RPDGFRA | |
| Hydrochloric Acid SCHEMBL30522741 | 0.82 | FLT3 (0.74) | FLT3PDGFRBKDRCSF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321568-B | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2023-02-17 | — | — | CN | claimed |
| CN-112321568-A | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2021-02-05 | — | — | CN | claimed |
| CN-112321568-B | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2023-02-17 | — | — | CN | disclosed |
| CN-112321568-A | 4-methylpyrrole substituted indolone derivative, preparation method and medical application thereof | 南京中医药大学 | 2021-02-05 | — | — | CN | disclosed |