SCHEMBL2854022

SCHEMBL2854022

Cc1ccc(Oc2ccc3nc(NC(=O)CCl)sc3n2)cc1NC(=O)c1cccc(C(C)(C)C#N)c1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDR P35968 10/20 0.47
BRAF P15056 18/20 0.47
RAF1 P04049 1/20 0.41
YES1 P07947 1/20 0.41
CYP2C9 P11712 2/20 0.40
HCK P08631 1/20 0.40
NR2C2 P49116 1/20 0.40
BTK Q06187 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2860356 0.93 BRAF (0.49) KDRBRAFRAF1YES1CYP2C9
SCHEMBL2857153 0.89 BRAF (0.59) KDRBRAFCYP2C9
SCHEMBL2193148 0.89 CASP2 (0.50) KDRBRAFRAF1YES1
SCHEMBL2851235 0.88 KDR (0.62) KDRBRAFRAF1
SCHEMBL2854372 0.88 KDR (0.48) KDRBRAFRAF1YES1
SCHEMBL2861306 0.87 BRAF (0.50) KDRBRAFCYP2C9
SCHEMBL2855455 0.87 KDR (0.45) KDRBRAFRAF1YES1CYP2C9
SCHEMBL13354082 0.87 KDR (0.44) KDRBRAFRAF1YES1
SCHEMBL2856543 0.86 BRAF (0.46) KDRBRAFRAF1YES1CYP2C9
SCHEMBL2851666 0.85 KDR (0.52) KDRBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108139671-B Photosensitive resin composition and cured film prepared therefrom 罗门哈斯电子材料韩国有限公司 2022-02-11 CN disclosed
US-10890846-B2 Photosensitive resin composition and cured film prepared therefrom ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD (KR) 2021-01-12 US disclosed
US-20180314153-A1 PHOTOSENSITIVE RESIN COMPOSITION AND CURED FILM PREPARED THEREFROM ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2018-11-01 US disclosed
US-9758694-B2 Curable resin composition, cured product thereof, and semiconductor device using the same CENTRAL GLASS COMPANY, LIMITED (JP) 2017-09-12 US disclosed
EP-3048133-B1 CURABLE RESIN COMPOSITION, CURED PRODUCT THEREOF, AND SEMICONDUCTOR DEVICE USING THE SAME CENTRAL GLASS CO LTD (JP) 2017-03-01 EP disclosed
US-20160215168-A1 Curable Resin Composition, Cured Product Thereof, and Semiconductor Device Using the Same CENTRAL GLASS COMPANY, LIMITED (JP) 2016-07-28 US disclosed
EP-3048133-A1 CURABLE RESIN COMPOSITION, CURED PRODUCT THEREOF, AND SEMICONDUCTOR DEVICE USING THE SAME Central Glass Company, Limited (JP) 2016-07-27 EP disclosed
EP-2184285-B1 HETEROCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2015-11-04 EP disclosed
US-8344135-B2 Heterocyclic compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-01-01 US disclosed
US-20100249119-A1 HETEROCYCLIC COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-09-30 US disclosed
EP-2184285-A1 HETEROCYCLIC COMPOUND AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2010-05-12 EP disclosed
US-20100007698-A1 LIQUID EJECTION HEAD AND PROCESS FOR PRODUCING THE SAME CANON KABUSHIKI KAISHA (JP) 2010-01-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249119-A1 HETEROCYCLIC COMPOUND AND USE THEREOF BRAF, NRAS, RAF1 KDR 983/4885BRAF 1/4885RAF1 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.