SCHEMBL28540904

SCHEMBL28540904

CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(B(O)O)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24759683 0.86 RORC (0.89) RORC
SCHEMBL17187032 0.83 RORC (0.71) RORC
SCHEMBL14744474 0.83 RORC (0.71) RORC
SCHEMBL18275042 0.82 RORC (0.74) RORC
SCHEMBL21741399 0.81 RORC (0.68) RORC
SCHEMBL21616659 0.81 RORC (0.67) RORC
SCHEMBL28712570 0.80 RORC (0.70) RORC
SCHEMBL19630584 0.80 RORC (0.67) RORC
SCHEMBL18275072 0.80 RORC (0.68) RORC
SCHEMBL14744195 0.80 RORC (0.57) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113072521-B ROR gamma t inhibitor and application thereof in medicines 广东东阳光药业股份有限公司 2024-04-05 CN disclosed
CN-112513021-B ROR gamma antagonist and application thereof in medicines 广东东阳光药业有限公司 2023-06-27 CN disclosed
CN-113072521-A ROR gamma t inhibitor and application thereof in medicine 广东东阳光药业有限公司 2021-07-06 CN disclosed
CN-112513021-A ROR gamma antagonist and application thereof in medicine 广东东阳光药业有限公司 2021-03-16 CN disclosed