Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | NPM1 | P06748 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30626523 | 0.95 | EGFR (0.59) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28531358 | 0.95 | EGFR (0.59) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28538542 | 0.94 | EGFR (0.59) | EGFR | |
| SCHEMBL28542534 | 0.93 | EGFR (0.56) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28537031 | 0.92 | EGFR (0.56) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28535440 | 0.92 | EGFR (0.56) | EGFR | |
| SCHEMBL22804355 | 0.92 | EGFR (0.59) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL28527856 | 0.91 | EGFR (0.60) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL25144770 | 0.90 | EGFR (0.69) | EGFR | |
| SCHEMBL22025902 | 0.90 | EGFR (0.81) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513029-A | Nitrogen-containing aryl phosphorus oxide derivative, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-03-16 | — | — | CN | disclosed |