Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.60 |
| ▸ | RXRB | P28702 | 2/20 | 0.60 |
| ▸ | RXRG | P48443 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23226557 | 0.89 | PTPN1 (0.61) | RXRARXRBRXRGMRGPRX4MCL1 | |
| SCHEMBL19667112 | 0.89 | MCL1 (0.54) | RXRARXRBRXRGKDM4EUSP2 | |
| SCHEMBL31406760 | 0.89 | RXRA (0.58) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL4200632 | 0.89 | LRRK2 (0.63) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL11768921 | 0.87 | LRRK2 (0.61) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL21436902 | 0.87 | RXRA (0.56) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL28558879 | 0.86 | MRGPRX4 (0.57) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL2451483 | 0.84 | RXRA (0.58) | RXRARXRBRXRGALDH1A1MRGPRX4 | |
| SCHEMBL27354625 | 0.84 | LRRK2 (0.55) | RXRARXRBRXRGMRGPRX4LRRK2 | |
| SCHEMBL27354622 | 0.84 | LRRK2 (0.55) | RXRARXRBRXRGMRGPRX4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111995567-B | Formamide pyridone iron chelator derivative with potential multi-target anti-AD activity and preparation method and application thereof | 浙江工业大学 | 2022-11-25 | — | — | CN | disclosed |
| CN-111995567-A | Formamide pyridone iron chelator derivative with potential multi-target anti-AD activity and preparation method and application thereof | 浙江工业大学 | 2020-11-27 | — | — | CN | disclosed |