Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.63 |
| ▸ | MEN1 | O00255 | 12/20 | 0.63 |
| ▸ | NPC1 | O15118 | 11/20 | 0.63 |
| ▸ | RAB9A | P51151 | 10/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | CD74 | P04233 | 1/20 | 0.59 |
| ▸ | MIF | P14174 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856921 | 1.00 | KMT2A (0.63) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL2854566 | 1.00 | KMT2A (0.63) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL3551268 | 0.85 | KMT2A (0.61) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL3551272 | 0.85 | KMT2A (0.61) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL2134734 | 0.83 | LMNA (0.58) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL2134737 | 0.83 | LMNA (0.58) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL10309021 | 0.80 | PFKFB3 (0.74) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL10275161 | 0.80 | PFKFB3 (0.74) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL12066587 | 0.79 | KMT2A (0.62) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL7513553 | 0.79 | KMT2A (0.62) | KMT2AMEN1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |
| EP-2027108-B1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LTD (GB) | 2010-01-13 | — | — | EP | disclosed |
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | US | disclosed |
| EP-2027108-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | Glaxo Group Limited (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135081-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | HRH2, HRH1, HRH4 | KMT2A 1661/4885MEN1 1110/4885NPC1 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.