Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348859 | 0.87 | SMN1; SMN2 (0.39) | KDM4EALDH1A1SMN1; SMN2L3MBTL1SCN5A | |
| SCHEMBL1348729 | 0.75 | LMNA (0.38) | KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1348596 | 0.71 | POLB (0.38) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1348807 | 0.70 | HPGD (0.43) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1348308 | 0.70 | HPGD (0.35) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1350177 | 0.70 | HPGD (0.43) | KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1348486 | 0.70 | CA12 (0.37) | KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1348507 | 0.69 | LMNA (0.38) | KDM4EALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1346184 | 0.69 | TTR (0.40) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1348845 | 0.68 | HPGD (0.35) | KDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863818-B1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-03-10 | — | — | EP | disclosed |