SCHEMBL28546386

SCHEMBL28546386

CSc1ccc(C(Cl)Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 9/20 0.50
TSHR P16473 1/20 0.43
ALDH1A1 P00352 1/20 0.41
MAOA P21397 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A3 Q01959 1/20 0.40
AKR1C3 P42330 3/20 0.37
AKR1C2 P52895 3/20 0.37
ACACB O00763 1/20 0.37
NOS3 P29474 1/20 0.37
NOS1 P29475 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12214194 0.78 SLC6A4 (0.54) SLC6A4ALDH1A1MAOASLC6A2SLC6A3
SCHEMBL4001233 0.78 TSHR (0.48) SLC6A4TSHRMAOANOS1
SCHEMBL11241713 0.77 SLC6A4 (0.59) SLC6A4MAOASLC6A2SLC6A3
SCHEMBL14033851 0.77 ALDH1A1 (0.45) SLC6A4TSHRALDH1A1AKR1C3AKR1C2
SCHEMBL5075045 0.76 TSHR (0.67) TSHR
SCHEMBL83839 0.76 ALDH1A1 (0.58) SLC6A4ALDH1A1MAOASLC6A2SLC6A3
SCHEMBL4556108 0.76 SLC6A4 (0.52) SLC6A4ALDH1A1MAOASLC6A2SLC6A3
SCHEMBL30610186 0.75 TSHR (0.56) SLC6A4TSHRALDH1A1MAOASLC6A2
SCHEMBL9318685 0.74 SLC6A4 (0.50) SLC6A4ALDH1A1MAOASLC6A2SLC6A3
SCHEMBL16147584 0.74 SLC6A4 (0.50) SLC6A4ALDH1A1MAOASLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112409225-B Synthetic method of p-methylsulfonylbenzaldehyde 山东国邦药业有限公司 2022-12-23 CN claimed
CN-112409225-A Synthetic method of p-methylsulfonylbenzaldehyde 山东国邦药业有限公司 2021-02-26 CN claimed
CN-112409225-B Synthetic method of p-methylsulfonylbenzaldehyde 山东国邦药业有限公司 2022-12-23 CN disclosed
CN-112409225-B Synthetic method of p-methylsulfonylbenzaldehyde 山东国邦药业有限公司 2022-12-23 CN disclosed
CN-112409225-A Synthetic method of p-methylsulfonylbenzaldehyde 山东国邦药业有限公司 2021-02-26 CN disclosed
CN-112409225-A Synthetic method of p-methylsulfonylbenzaldehyde 山东国邦药业有限公司 2021-02-26 CN disclosed