Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788605 | 1.00 | MEN1 (0.47) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL29632578 | 0.77 | KDM4E (0.36) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL24936302 | 0.77 | KDM4E (0.36) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL24977286 | 0.76 | EPHX2 (0.41) | KMT2AKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL11022631 | 0.74 | TP53 (0.67) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL23084830 | 0.73 | KDM4E (0.45) | KDM4EALDH1A1MAPTCA1GAA | |
| SCHEMBL2093729 | 0.73 | CYP1A2 (0.62) | TP53KDM4EALDH1A1CYP3A4HPGD | |
| Hydrochloric Acid SCHEMBL7232145 | 0.70 | MEN1 (0.50) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL7235549 | 0.69 | TP53 (0.53) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL17414696 | 0.68 | TP53 (0.57) | MEN1KMT2ATP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728945-B | 3, 5-disubstituted pyrazole compounds as kinase inhibitors and uses thereof | 上海瑛派药业有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-114728945-A | 3, 5-disubstituted pyrazole compounds as kinase inhibitors and application thereof | 上海瑛派药业有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-112457306-A | 3, 5-disubstituted pyrazole compounds as kinase inhibitors and application thereof | 上海瑛派药业有限公司 | 2021-03-09 | — | — | CN | disclosed |