Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | APAF1 | O14727 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HTR1E | P28566 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28548649 | 1.00 | KDM4E (0.62) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL28564727 | 0.86 | KDM4E (0.59) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL28564728 | 0.86 | KDM4E (0.59) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL27484962 | 0.84 | MAPT (0.59) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL27484963 | 0.84 | MAPT (0.59) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL28561983 | 0.82 | MAPT (0.57) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL28561984 | 0.82 | MAPT (0.57) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL4110000 | 0.82 | KDM4E (0.53) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL28905679 | 0.82 | HTR2A (0.64) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL4108551 | 0.82 | MMP9 (0.57) | KDM4EMAPTPOLBAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239948-A | Solid forms and methods of making fused tricyclic compounds, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117946107-A | Solid forms and methods of making fused tricyclic compounds, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-112437685-A | Solid forms of 3- ((1R,3R) -1- (2, 6-difluoro-4- ((1- (3-fluoropropyl) azetidin-3-yl) amino) phenyl) -3-methyl-1, 3,4, 9-tetrahydro-2H-pyrido [3,4-b ] indol-2-yl) -2, 2-difluoropropan-1-ol and methods of making fused tricyclic compounds containing a substituted phenyl or pyridinyl moiety, including methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-03-02 | — | — | CN | disclosed |