SCHEMBL28548660

SCHEMBL28548660

C/C(Cl)=C\CN1CCCCC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
CHRNA4 P43681 1/20 0.44
ALDH1A1 P00352 4/20 0.39
KMT2A Q03164 5/20 0.38
MEN1 O00255 4/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPK1 P28482 2/20 0.35
LMNA P02545 2/20 0.35
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
HRH3 Q9Y5N1 1/20 0.33
CARM1 Q86X55 1/20 0.33
PRMT6 Q96LA8 1/20 0.33
PRMT8 Q9NR22 1/20 0.33
HTT P42858 1/20 0.33
CHRM1 P11229 1/20 0.33
ADRA2B P18089 1/20 0.33
SLC6A4 P31645 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27918887 1.00 CHRNB2 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL10762638 0.81 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA4KMT2A
SCHEMBL15901764 0.81 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA4KMT2A
SCHEMBL16103861 0.80 PAOX (0.37) ALDH1A1KMT2AMEN1SMN1; SMN2MAPK1
SCHEMBL15901179 0.78 CHRNB2 (0.42) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL31546350 0.78 CHRNB2 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL7704824 0.76 CHRNB2 (0.43) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL7704822 0.76 CHRNB2 (0.43) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL7708146 0.76 CHRNB2 (0.43) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL9281063 0.74 CHRNB2 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112707869-B Dacotinib impurity and preparation method thereof 扬子江药业集团有限公司 2022-03-22 CN disclosed
CN-112707869-A Dacotinib impurity and preparation method thereof 扬子江药业集团有限公司 2021-04-27 CN disclosed