Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.41 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL28242594 | 0.96 | GSR (0.56) | GSRPTGS1SLC7A11OTCCPB2 | |
| Arginine SCHEMBL28527646 | 0.96 | GSR (0.56) | GSRPTGS1SLC7A11OTCCPB2 | |
| Arginine SCHEMBL27757865 | 0.95 | GSR (0.47) | GSRPTGS1SLC7A11OTCCPB2 | |
| Arginine SCHEMBL16637167 | 0.95 | PTGS1 (0.46) | GSRPTGS1SLC7A11OTCDDAH1 | |
| Arginine SCHEMBL28213703 | 0.95 | PTGS1 (0.46) | GSRPTGS1SLC7A11OTCDDAH1 | |
| Arginine SCHEMBL20678167 | 0.95 | PTGS1 (0.46) | GSRPTGS1SLC7A11OTCDDAH1 | |
| Arginine SCHEMBL22207237 | 0.93 | GSR (0.59) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL18149040 | 0.93 | GSR (0.59) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL18149039 | 0.93 | GSR (0.59) | GSROTCGNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL1696994 | 0.93 | GSR (0.59) | GSROTCGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109701040-B | Nano PAMAM (polyamidoamine) targeted polypeptide radionuclide preparation for diagnosing and treating MTC (MTC) and preparation method thereof | 昆明医科大学第一附属医院 | 2021-04-06 | — | — | CN | disclosed |