Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.46 |
| ▸ | OTC | P00480 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.42 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 4/20 | 0.40 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16637167 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL20678167 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL28548707 | 0.95 | GSR (0.51) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL22360939 | 0.95 | PTGS1 (0.41) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL909965 | 0.95 | PTGS1 (0.41) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL20678185 | 0.95 | PTGS1 (0.41) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL1278091 | 0.95 | PTGS1 (0.41) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL5586520 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL3487131 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1GSR | |
| Arginine SCHEMBL3487127 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11OTCDDAH1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107936267-A | A kind of preparation method and expansion of stem cells and collection method of two ionic starch base expansion of stem cells hydrogel | 天津大学 | 2018-04-20 | — | — | CN | claimed |