SCHEMBL28548736

SCHEMBL28548736

COc1ccc(NCc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.64
GAA P10253 3/20 0.64
RAB9A P51151 3/20 0.64
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
NPC1 O15118 2/20 0.64
L3MBTL1 Q9Y468 2/20 0.64
CACNA1B Q00975 2/20 0.59
LMNA P02545 1/20 0.56
KDM4E B2RXH2 1/20 0.56
ALDH1A1 P00352 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA9 Q16790 1/20 0.56
FFAR1 O14842 2/20 0.55
HIF1A Q16665 1/20 0.54
ERBB2 P04626 1/20 0.53
TUBB4A P04350 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7345712 0.86 FFAR1 (0.68) MAPTCACNA1BALDH1A1CA12CA1
SCHEMBL5669873 0.86 MAPT (0.82) MAPTGAARAB9AMEN1KMT2A
SCHEMBL1844199 0.86 MAPT (0.82) MAPTGAARAB9AMEN1KMT2A
SCHEMBL10055019 0.86 MAPT (0.82) MAPTGAARAB9AMEN1KMT2A
SCHEMBL1581519 0.86 MAPT (0.69) MAPTGAARAB9AMEN1KMT2A
SCHEMBL12933320 0.85 MAPT (0.66) MAPTGAARAB9AMEN1KMT2A
SCHEMBL30301290 0.85 MAPT (0.66) MAPTGAARAB9AMEN1KMT2A
SCHEMBL4433139 0.83 MAPT (0.57) MAPTGAAMEN1KMT2ACACNA1B
Hydrochloric Acid SCHEMBL4441377 0.82 MAPT (0.56) MAPTGAARAB9AMEN1KMT2A
SCHEMBL22298750 0.81 KIF11 (0.61) CACNA1BALDH1A1CA1CA2FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112679541-A Preparation method and application of metal organic ternary cyclic compound 大连理工大学 2021-04-20 CN claimed
EP-3707132-B1 NEW METHOD FOR THE SYNTHESIS OF UNSYMMETRICAL TERTIARY AMINES UNIV PARIS SACLAY (FR) 2024-07-17 EP disclosed
CN-112679541-B Preparation method and application of metal organic ternary cyclic compound 大连理工大学 2022-03-18 CN disclosed
CN-112679541-A Preparation method and application of metal organic ternary cyclic compound 大连理工大学 2021-04-20 CN disclosed