Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8144149 | 0.80 | MAPT (0.61) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL25487988 | 0.80 | KDM4E (0.54) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL12489213 | 0.79 | MAPT (0.52) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL566054 | 0.76 | MAPT (0.52) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL12986264 | 0.75 | MAPT (0.52) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL1998666 | 0.75 | MAPT (0.52) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL21872084 | 0.75 | MAPT (0.47) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL21871906 | 0.75 | MAPT (0.47) | MAPTKDM4ELRRK2CYP3A4LMNA | |
| SCHEMBL25156689 | 0.74 | HTT (0.44) | MAPTKDM4ELRRK2MEN1HTT | |
| SCHEMBL1997158 | 0.72 | LMNA (0.51) | MAPTKDM4ELRRK2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638901-A | Novel pyrrolidinylamide compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2021-04-09 | — | — | CN | disclosed |