SCHEMBL28548835

SCHEMBL28548835

Clc1ccc(-c2cc(-c3cccc(-c4cccnc4)c3)nc(-c3ccc4c(ccc5ccccc54)c3)n2)cc1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 8/20 0.50
CYP11B2 P19099 7/20 0.50
CYP19A1 P11511 6/20 0.50
CYP17A1 P05093 2/20 0.50
PSD A5PKW4 1/20 0.45
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
HSD17B1 P14061 1/20 0.42
CYP2B6 P20813 1/20 0.42
CYP2C19 P33261 1/20 0.42
HSD17B2 P37059 1/20 0.42
ERN1 O75460 1/20 0.42
DHODH Q02127 1/20 0.41
PGR P06401 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.40
CNR1 P21554 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30857474 1.00 CYP11B1 (0.50) CYP11B1CYP11B2CYP19A1CYP17A1PSD
SCHEMBL30857479 0.93 CYP11B1 (0.55) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL24252594 0.93 CYP11B1 (0.55) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL21841073 0.88 CYP11B1 (0.56) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL24252714 0.84 CYP11B1 (0.52) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL17808030 0.84 CYP11B1 (0.58) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL17808026 0.84 CYP11B2 (0.59) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL17808144 0.84 CYP11B2 (0.59) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL17808029 0.83 CYP11B2 (0.62) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2
SCHEMBL17918138 0.83 CYP11B2 (0.62) CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112654611-B Compound having pyrimidine ring structure and organic electroluminescent element 保土谷化学工业株式会社 2024-04-30 CN disclosed
CN-112654611-A Compound having pyrimidine ring structure and organic electroluminescent element 保土谷化学工业株式会社 2021-04-13 CN disclosed