Phenytoin

Phenytoin

SCHEMBL28548871

Br.O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Phenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A known ✓ P35498 1/20 0.96
SCN4A known ✓ P35499 1/20 0.96
SCN5A known ✓ Q14524 1/20 0.96
SCN2A known ✓ Q99250 1/20 0.96
SCN3A known ✓ Q9NY46 1/20 0.96
CYP2C9 P11712 2/20 0.96
CACNA1F O60840 1/20 0.96
ALDH1A1 P00352 1/20 0.96
MAPT P10636 1/20 0.96
HTR2A P28223 1/20 0.96
HRH1 P35367 1/20 0.96
BLM P54132 1/20 0.96
PMP22 Q01453 1/20 0.96
CACNA1D Q01668 1/20 0.96
KCNH2 Q12809 1/20 0.96
CACNA1S Q13698 1/20 0.96
CACNA1C Q13936 1/20 0.96
AKR1B1 P15121 3/20 0.76
ITGA4 P13612 1/20 0.57
GAA P10253 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenytoin SCHEMBL5499612 0.98 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL3440 0.98 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL5160618 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL157671 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL29521348 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL1461588 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2140317 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2905857 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL10406406 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL6730646 0.96 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115197441-A Biological gel and energy-saving process thereof 连云港东朗新材料科技有限公司 2022-10-18 CN disclosed
CN-112979438-A Preparation method of benzophenone 江西仰立新材料有限公司 2021-06-18 CN disclosed
CN-108558625-B Synthesis method of boron trifluoride catalyzed benzophenone compound 三峡大学 2021-05-18 CN disclosed
CN-108947785-B Method for synthesizing benzophenone by photocatalysis 湖南大学 2021-03-26 CN disclosed