Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ACP1 | P24666 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28551149 | 0.88 | KDM4E (0.63) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28207160 | 0.87 | KMT2A (0.55) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28537294 | 0.87 | KMT2A (0.57) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28955063 | 0.86 | KDM4E (0.56) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28207630 | 0.83 | KMT2A (0.57) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28207162 | 0.83 | POLB (0.57) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28541749 | 0.83 | MAPK1 (0.60) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28207096 | 0.83 | FLT3 (0.59) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28207093 | 0.82 | KDM4E (0.55) | KMT2AKDM4EPOLBLMNAGAA | |
| SCHEMBL28207090 | 0.79 | NME2 (0.54) | KMT2AKDM4EPOLBLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107868060-B | 2- [3- (4-morpholinyl) propylamino ] -3-aryl-4-quinolinone compounds and application thereof | 沈阳药科大学 | 2021-04-09 | — | — | CN | claimed |
| CN-107868060-B | 2- [3- (4-morpholinyl) propylamino ] -3-aryl-4-quinolinone compounds and application thereof | 沈阳药科大学 | 2021-04-09 | — | — | CN | disclosed |