SCHEMBL28550669

SCHEMBL28550669

O=C(O)n1c(=O)[nH]c2ncccc21

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
DAO P14920 3/20 0.63
FEN1 P39748 1/20 0.47
ADORA3 P0DMS8 1/20 0.42
ITGB1 P05556 3/20 0.40
ITGAV P06756 3/20 0.40
ITGA5 P08648 3/20 0.40
ITGA4 P13612 3/20 0.40
ITGB8 P26012 2/20 0.40
TNKS O95271 2/20 0.40
TNKS2 Q9H2K2 1/20 0.40
ITGB6 P18564 1/20 0.39
CALCRL Q16602 3/20 0.39
ALDH1A1 P00352 1/20 0.38
PRKCQ Q04759 1/20 0.38
AURKA O14965 1/20 0.38
PARP1 P09874 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21385026 0.78 DAO (0.52) DAOFEN1ALDH1A1PRKCQ
SCHEMBL9850691 0.74 DAO (0.55) DAOFEN1ITGB1ITGAVITGA5
SCHEMBL29745083 0.74 DAO (0.64) DAOFEN1ADORA3ALDH1A1PRKCQ
SCHEMBL7906060 0.74 DAO (0.64) DAOFEN1ADORA3TNKSTNKS2
SCHEMBL1163568 0.74 DAO (0.64) DAOFEN1ADORA3ALDH1A1PRKCQ
SCHEMBL12087670 0.74 DAO (0.64) DAOFEN1ADORA3TNKSTNKS2
SCHEMBL11511885 0.73 DAO (0.58) DAOFEN1ADORA3ALDH1A1PRKCQ
SCHEMBL29038509 0.73 DAO (0.63) DAOFEN1TNKSTNKS2ALDH1A1
SCHEMBL2071214 0.73 ASAH1 (0.57) DAO
SCHEMBL530180 0.73 DAO (0.54) DAOFEN1CALCRLALDH1A1PRKCQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4737458-A2 PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS Merck Sharp & Dohme LLC (US) 2026-05-06 EP disclosed
CN-112585137-A Pesticidally active bicyclic heteroaromatic compounds 先正达农作物保护股份公司 2021-03-30 CN disclosed