Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28552131 | 1.00 | JAK1 (0.44) | JAK1JAK2DRD2KDM1AMAOB | |
| SCHEMBL25674514 | 0.90 | KMT2A (0.46) | JAK1JAK2DRD2KDM1AMAOB | |
| SCHEMBL30464462 | 0.90 | KMT2A (0.46) | JAK1JAK2DRD2KDM1AMAOB | |
| SCHEMBL28542915 | 0.84 | JAK1 (0.47) | JAK1JAK2DRD2KDM1AMAOB | |
| SCHEMBL28542917 | 0.84 | JAK1 (0.47) | JAK1JAK2DRD2KDM1AMAOB | |
| SCHEMBL30491703 | 0.83 | GPR119 (0.52) | ALDH1A1 | |
| SCHEMBL14909505 | 0.82 | TDP1 (0.44) | L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL17619666 | 0.81 | JAK1 (0.43) | JAK1JAK2DRD2KDM1AMAOB | |
| SCHEMBL25251022 | 0.79 | GPR119 (0.47) | — | |
| SCHEMBL17619522 | 0.77 | CKS1B (0.48) | JAK1JAK2DRD2KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112585119-A | Substituted indoles and methods of use thereof | EPIZYME股份有限公司 | 2021-03-30 | — | — | CN | disclosed |