Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.74 |
| ▸ | EGFR | P00533 | 11/20 | 0.74 |
| ▸ | SRC | P12931 | 11/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.74 |
| ▸ | ABL1 | P00519 | 7/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.74 |
| ▸ | STAT5A | P42229 | 1/20 | 0.73 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.73 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.73 |
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | WEE1 | P30291 | 3/20 | 0.67 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.67 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.67 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.67 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.62 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.62 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.62 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.62 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762046 | 0.85 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL29765306 | 0.85 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL30257377 | 0.85 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL29378902 | 0.85 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL256711 | 0.85 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL13498143 | 0.84 | FGFR1 (0.83) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL1334768 | 0.82 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5764062 | 0.82 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL3360316 | 0.81 | FGFR1 (0.74) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL1249524 | 0.81 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112755193-A | Method of treating malignancies with anti-tyrosine kinase inhibitors using dianhydrogalactitol or a derivative thereof | 德玛医药 | 2021-05-07 | — | — | CN | disclosed |