Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 8/20 | 0.46 |
| ▸ | ATF1 | P18846 | 5/20 | 0.46 |
| ▸ | XPO1 | O14980 | 5/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 4/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.40 |
| ▸ | RELA | Q04206 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30421442 | 1.00 | NFKB1 (0.46) | NFKB1ATF1XPO1NR3C1STK17B | |
| SCHEMBL30881391 | 0.85 | STK17B (0.43) | NFKB1ATF1XPO1STK17BSTK17A | |
| SCHEMBL27244007 | 0.85 | STK17B (0.43) | NFKB1ATF1XPO1STK17BSTK17A | |
| SCHEMBL20558363 | 0.81 | LCK (0.47) | XPO1STK17BSTK17ARAB9ANPC1 | |
| SCHEMBL31521363 | 0.78 | STK17B (0.50) | STK17BSTK17ARAB9ANPC1ALDH1A1 | |
| SCHEMBL30421262 | 0.74 | NFKB1 (0.61) | NFKB1ATF1XPO1NR3C1KCNQ3 | |
| SCHEMBL28557381 | 0.74 | NFKB1 (0.61) | NFKB1ATF1XPO1NR3C1KCNQ3 | |
| SCHEMBL12942868 | 0.73 | SYK (0.47) | XPO1STK17BSTK17A | |
| SCHEMBL31606832 | 0.72 | GAA (0.50) | RAB9ANPC1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL22145335 | 0.71 | NFKB1 (0.47) | NFKB1ATF1XPO1STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759594-B | Substituted pyrazolopyrimidine TAM inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-112759594-A | Substituted pyrazolopyrimidine TAM inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2021-05-07 | — | — | CN | disclosed |