Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201800 | 0.98 | PPARA (0.51) | PPARALPAR1LPAR2LPAR3FAAH | |
| SCHEMBL9351056 | 0.98 | PPARA (0.51) | PPARALPAR1LPAR2LPAR3FAAH | |
| Bromide SCHEMBL28566280 | 0.96 | PPARA (0.50) | PPARALPAR1LPAR2LPAR3FAAH | |
| SCHEMBL24569080 | 0.91 | PPARA (0.51) | PPARALPAR1LPAR2LPAR3FAAH | |
| Bromide SCHEMBL28560379 | 0.88 | CA1 (0.40) | PPARAEPHX2 | |
| Bromide SCHEMBL28566272 | 0.88 | CA1 (0.40) | PPARAEPHX2 | |
| SCHEMBL7920142 | 0.86 | CA1 (0.41) | PPARAEPHX2 | |
| SCHEMBL444025 | 0.86 | CA1 (0.41) | PPARAEPHX2 | |
| SCHEMBL10822147 | 0.86 | CA1 (0.41) | PPARAEPHX2 | |
| SCHEMBL446394 | 0.86 | CA1 (0.41) | PPARAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118271422-A | Transfection complexes and methods of use thereof | 分子传递有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-108358812-B | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-05-11 | — | — | CN | claimed |
| CN-118271422-A | Transfection complexes and methods of use thereof | 分子传递有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-114761376-A | Amine-containing transfection reagent, preparation method and transfection compound | 苏州瑞博生物技术股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-113214102-A | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-108358812-B | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-05-11 | — | — | CN | disclosed |