Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28559142 | 0.96 | PPARA (0.50) | PPARALPAR2LPAR3LPAR1EPHX2 | |
| SCHEMBL9351056 | 0.94 | PPARA (0.51) | PPARALPAR2LPAR3LPAR1EPHX2 | |
| SCHEMBL8201800 | 0.94 | PPARA (0.51) | PPARALPAR2LPAR3LPAR1EPHX2 | |
| SCHEMBL24569080 | 0.87 | PPARA (0.51) | PPARALPAR2LPAR3LPAR1EPHX2 | |
| Bromide SCHEMBL28566272 | 0.84 | CA1 (0.40) | PPARAEPHX2 | |
| Bromide SCHEMBL28560379 | 0.84 | CA1 (0.40) | PPARAEPHX2 | |
| SCHEMBL7920142 | 0.82 | CA1 (0.41) | PPARAEPHX2 | |
| SCHEMBL179762 | 0.82 | CA1 (0.41) | PPARAEPHX2 | |
| SCHEMBL446394 | 0.82 | CA1 (0.41) | PPARAEPHX2 | |
| SCHEMBL10822147 | 0.82 | CA1 (0.41) | PPARAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302189-A | Coronavirus vaccine | 生物技术欧洲股份公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-118121722-A | RNA constructs and uses thereof | 生物技术欧洲股份公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-117750974-A | Viral vaccine | 生物技术欧洲股份公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-116194477-A | Binding agents to coronavirus S proteins | 生物技术欧洲股份公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-115843330-A | Coronavirus vaccine | 辉瑞公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-108601951-B | Immunomodulatory compositions for treatment | 金港医疗(澳大利亚)私人有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-115335084-A | RNA particles comprising polymyosine | 生物技术公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-115135335-A | In vitro and in vivo gene delivery to immune effector cells using nanoparticles functionalized with Designed Ankyrin Repeat Proteins (DARPIN) | 生物技术细胞和基因治疗公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-113521269-A | Coronavirus vaccine | 生物技术RNA制药有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-112867509-A | RNA particles comprising polymyosine | 约翰内斯·古滕伯格美因兹大学 | 2021-05-28 | — | — | CN | disclosed |